Drug interactions
Amlodipine-perindopril + Insulin detemir
Severity: Moderate
Amlodipine-perindopril and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering action of insulin. This can lead to episodes of hypoglycemia, mainly after starting the ACE inhibitor or in patients with good glycemic control.
What this interaction means in plain words
Amlodipine-perindopril and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Insulin detemir belongs to Endocrine.
Why it happens
ACE inhibition increases insulin sensitivity, possibly via increased bradykinin, producing additive glucose lowering.
What to do
Monitor blood glucose more frequently when perindopril is started or the dose changed. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Insulin detemir
Frequently asked questions
Can I take Amlodipine-perindopril with Insulin detemir?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering action of insulin. This can lead to episodes of hypoglycemia, mainly after starting the ACE inhibitor or in patients with good glycemic control.
How serious is the interaction between Amlodipine-perindopril and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when perindopril is started or the dose changed. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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