Drug interactions
Amlodipine-perindopril + Ketorolac intranasal
Severity: Major
Amlodipine-perindopril and Ketorolac intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed ketorolac can blunt perindopril's antihypertensive effect and, with an ACE inhibitor, can cause acute kidney injury, especially in volume-depleted or older patients.
What this interaction means in plain words
Amlodipine-perindopril and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular perfusion, compounding the effect of ACE inhibition on efferent arterioles.
What to do
Keep ketorolac to the shortest possible course with adequate hydration and monitor creatinine, potassium and blood pressure, or use a non-NSAID analgesic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Ketorolac intranasal?
MediHelp rates the interaction as major. Amlodipine-perindopril and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemically absorbed ketorolac can blunt perindopril's antihypertensive effect and, with an ACE inhibitor, can cause acute kidney injury, especially in volume-depleted or older patients.
How serious is the interaction between Amlodipine-perindopril and Ketorolac intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep ketorolac to the shortest possible course with adequate hydration and monitor creatinine, potassium and blood pressure, or use a non-NSAID analgesic.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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