Drug interactions
Amlodipine-perindopril + Ketorolac
Severity: Major
Amlodipine-perindopril and Ketorolac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac combined with perindopril increases the risk of acute kidney injury and blunts blood pressure control. Risk is greater with volume depletion, renal impairment and higher or prolonged ketorolac dosing.
What this interaction means in plain words
Amlodipine-perindopril and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-perindopril belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
Potent NSAID inhibition of prostaglandin synthesis reduces renal perfusion and causes sodium retention, opposing ACE inhibitor action.
What to do
Avoid in patients with renal impairment or volume depletion and limit ketorolac to the shortest course. Monitor creatinine, potassium and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Ketorolac?
MediHelp rates the interaction as major. Amlodipine-perindopril and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac combined with perindopril increases the risk of acute kidney injury and blunts blood pressure control. Risk is greater with volume depletion, renal impairment and higher or prolonged ketorolac dosing.
How serious is the interaction between Amlodipine-perindopril and Ketorolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with renal impairment or volume depletion and limit ketorolac to the shortest course. Monitor creatinine, potassium and blood pressure.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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