Drug interactions
Amlodipine-perindopril + Magnesium supplement
Severity: Minor
Amlodipine-perindopril and Magnesium supplement: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium has vasodilating and calcium-antagonist properties and may add to the hypotensive effect of amlodipine. High magnesium levels with calcium channel blockers can also worsen neuromuscular effects, mainly with parenteral magnesium.
What this interaction means in plain words
Amlodipine-perindopril and Magnesium supplement have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive vasodilation and calcium antagonism.
What to do
Monitor blood pressure, especially with intravenous magnesium. Oral supplements at usual doses generally need no change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Magnesium supplement?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Magnesium supplement have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Magnesium has vasodilating and calcium-antagonist properties and may add to the hypotensive effect of amlodipine. High magnesium levels with calcium channel blockers can also worsen neuromuscular effects, mainly with parenteral magnesium.
How serious is the interaction between Amlodipine-perindopril and Magnesium supplement?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially with intravenous magnesium. Oral supplements at usual doses generally need no change.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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