Drug interactions
Amlodipine-perindopril + Metformin
Severity: Minor
Amlodipine-perindopril and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase insulin sensitivity and modestly increase hypoglycemia risk with antidiabetic drugs, while calcium channel blockers can occasionally worsen glycemic control. In patients with renal impairment, ACE inhibitors may also reduce kidney function and raise metformin accumulation risk.
What this interaction means in plain words
Amlodipine-perindopril and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Opposing minor effects on glucose handling plus possible ACE inhibitor related changes in renal function affecting metformin clearance.
What to do
Monitor blood glucose and renal function periodically, particularly after starting perindopril. Review metformin dosing if eGFR declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Metformin
Frequently asked questions
Can I take Amlodipine-perindopril with Metformin?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors may increase insulin sensitivity and modestly increase hypoglycemia risk with antidiabetic drugs, while calcium channel blockers can occasionally worsen glycemic control. In patients with renal impairment, ACE inhibitors may also reduce kidney function and raise metformin accumulation risk.
How serious is the interaction between Amlodipine-perindopril and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function periodically, particularly after starting perindopril. Review metformin dosing if eGFR declines.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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