Drug interactions
Amlodipine-perindopril + Nesiritide
Severity: Moderate
Amlodipine-perindopril and Nesiritide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nesiritide is a potent intravenous vasodilator, and combining it with an ACE inhibitor and a calcium channel blocker can produce additive blood pressure lowering. Symptomatic hypotension may occur, particularly in volume-depleted patients or those with renal impairment.
What this interaction means in plain words
Amlodipine-perindopril and Nesiritide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure reduction from three agents acting through different pathways.
What to do
Monitor blood pressure closely during nesiritide infusion and reduce the infusion rate or hold oral antihypertensives if hypotension develops. Check renal function in patients on prolonged infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Nesiritide?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Nesiritide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nesiritide is a potent intravenous vasodilator, and combining it with an ACE inhibitor and a calcium channel blocker can produce additive blood pressure lowering. Symptomatic hypotension may occur, particularly in volume-depleted patients or those with renal impairment.
How serious is the interaction between Amlodipine-perindopril and Nesiritide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during nesiritide infusion and reduce the infusion rate or hold oral antihypertensives if hypotension develops. Check renal function in patients on prolonged infusion.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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