Drug interactions
Amlodipine-perindopril + Nitroglycerin sublingual
Severity: Moderate
Amlodipine-perindopril and Nitroglycerin sublingual: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine, perindopril and nitroglycerin all lower blood pressure through different mechanisms, so the effects add up. Marked orthostatic hypotension, dizziness or syncope can occur after sublingual doses.
What this interaction means in plain words
Amlodipine-perindopril and Nitroglycerin sublingual can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and blood pressure reduction through calcium channel blockade, ACE inhibition and nitrate-mediated venodilation.
What to do
Advise patients to sit before taking sublingual nitroglycerin and to rise slowly. Monitor blood pressure, especially when starting or adjusting therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-perindopril and Nitroglycerin sublingual, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Nitroglycerin sublingual?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Nitroglycerin sublingual can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine, perindopril and nitroglycerin all lower blood pressure through different mechanisms, so the effects add up. Marked orthostatic hypotension, dizziness or syncope can occur after sublingual doses.
How serious is the interaction between Amlodipine-perindopril and Nitroglycerin sublingual?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to sit before taking sublingual nitroglycerin and to rise slowly. Monitor blood pressure, especially when starting or adjusting therapy.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
