Drug interactions
Amlodipine-perindopril + Nitroprusside
Severity: Moderate
Amlodipine-perindopril and Nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium nitroprusside is a powerful intravenous vasodilator, and concurrent amlodipine and perindopril can magnify the fall in blood pressure. Excessive hypotension may occur rapidly.
What this interaction means in plain words
Amlodipine-perindopril and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic vasodilation and reduced vascular resistance from combined nitric oxide donation, calcium channel blockade and ACE inhibition.
What to do
Titrate nitroprusside with continuous blood pressure monitoring, ideally with arterial line, and anticipate lower infusion requirements. Consider holding oral antihypertensives during the infusion if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Nitroprusside?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium nitroprusside is a powerful intravenous vasodilator, and concurrent amlodipine and perindopril can magnify the fall in blood pressure. Excessive hypotension may occur rapidly.
How serious is the interaction between Amlodipine-perindopril and Nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate nitroprusside with continuous blood pressure monitoring, ideally with arterial line, and anticipate lower infusion requirements. Consider holding oral antihypertensives during the infusion if hypotension occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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