Drug interactions
Amlodipine-perindopril + Olanzapine / samidorphan
Severity: Moderate
Amlodipine-perindopril and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine causes orthostatic hypotension and may enhance the effect of antihypertensives. Patients taking amlodipine and perindopril may have exaggerated blood pressure falls.
What this interaction means in plain words
Amlodipine-perindopril and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from olanzapine alpha-1 adrenergic antagonism with the antihypertensives.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating olanzapine. Reduce the antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine causes orthostatic hypotension and may enhance the effect of antihypertensives. Patients taking amlodipine and perindopril may have exaggerated blood pressure falls.
How serious is the interaction between Amlodipine-perindopril and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating olanzapine. Reduce the antihypertensive dose if hypotension develops.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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