Drug interactions
Amlodipine-perindopril + Pentobarbital
Severity: Moderate
Amlodipine-perindopril and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital can induce CYP3A4 and reduce amlodipine exposure, potentially weakening blood pressure control. The effect develops over days with repeated barbiturate use.
What this interaction means in plain words
Amlodipine-perindopril and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of hepatic and intestinal CYP3A4 increases amlodipine metabolism.
What to do
Monitor blood pressure when pentobarbital is started or stopped, and increase the amlodipine dose if control is lost. Reassess the dose after the barbiturate is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Pentobarbital?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital can induce CYP3A4 and reduce amlodipine exposure, potentially weakening blood pressure control. The effect develops over days with repeated barbiturate use.
How serious is the interaction between Amlodipine-perindopril and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when pentobarbital is started or stopped, and increase the amlodipine dose if control is lost. Reassess the dose after the barbiturate is discontinued.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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