Drug interactions
Amlodipine-perindopril + Phenoxybenzamine
Severity: Moderate
Amlodipine-perindopril and Phenoxybenzamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine is a long-acting alpha-blocker that causes marked vasodilation, so adding amlodipine and perindopril can lead to pronounced hypotension. First-dose or dose-increase hypotension and orthostatic symptoms are especially likely.
What this interaction means in plain words
Amlodipine-perindopril and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic blood pressure lowering from alpha-adrenergic blockade, calcium channel blockade and ACE inhibition.
What to do
Monitor supine and standing blood pressure when starting or adjusting any of the drugs, and titrate doses gradually. Counsel patients about orthostatic dizziness and syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Phenoxybenzamine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine is a long-acting alpha-blocker that causes marked vasodilation, so adding amlodipine and perindopril can lead to pronounced hypotension. First-dose or dose-increase hypotension and orthostatic symptoms are especially likely.
How serious is the interaction between Amlodipine-perindopril and Phenoxybenzamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when starting or adjusting any of the drugs, and titrate doses gradually. Counsel patients about orthostatic dizziness and syncope.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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