Drug interactions
Amlodipine-perindopril + Phenytoin
Severity: Moderate
Amlodipine-perindopril and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine has been reported to raise phenytoin levels, though the evidence is limited. Phenytoin is also a CYP3A4 inducer and may lower amlodipine concentrations, so the net effect is unpredictable.
What this interaction means in plain words
Amlodipine-perindopril and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Phenytoin belongs to Central Nervous System.
Why it happens
Possible altered CYP-mediated metabolism of phenytoin by amlodipine, while phenytoin induces CYP3A4 metabolism of amlodipine.
What to do
Monitor phenytoin serum concentrations and signs of toxicity such as nystagmus or ataxia after starting amlodipine. Also monitor blood pressure, and adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Phenytoin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine has been reported to raise phenytoin levels, though the evidence is limited. Phenytoin is also a CYP3A4 inducer and may lower amlodipine concentrations, so the net effect is unpredictable.
How serious is the interaction between Amlodipine-perindopril and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin serum concentrations and signs of toxicity such as nystagmus or ataxia after starting amlodipine. Also monitor blood pressure, and adjust doses as needed.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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