Drug interactions
Amlodipine-perindopril + Prazosin
Severity: Moderate
Amlodipine-perindopril and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prazosin is an alpha-1 blocker that causes vasodilation and can produce marked postural hypotension after the first dose. Adding amlodipine and perindopril increases the blood pressure lowering effect, raising the chance of dizziness, syncope and falls.
What this interaction means in plain words
Amlodipine-perindopril and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Prazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure lowering through alpha-1 blockade, calcium channel blockade and ACE inhibition.
What to do
Start prazosin at a low dose at bedtime and titrate slowly, advising the patient to rise gradually. Monitor standing and sitting blood pressure after initiation and dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Amlodipine-perindopril with Prazosin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prazosin is an alpha-1 blocker that causes vasodilation and can produce marked postural hypotension after the first dose. Adding amlodipine and perindopril increases the blood pressure lowering effect, raising the chance of dizziness, syncope and falls.
How serious is the interaction between Amlodipine-perindopril and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start prazosin at a low dose at bedtime and titrate slowly, advising the patient to rise gradually. Monitor standing and sitting blood pressure after initiation and dose changes.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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