Drug interactions
Amlodipine-perindopril + Rifampin
Severity: Moderate
Amlodipine-perindopril and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent enzyme inducer and can substantially lower amlodipine exposure, reducing its antihypertensive effect. Loss of blood pressure control may develop over one to two weeks.
What this interaction means in plain words
Amlodipine-perindopril and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP3A4 and intestinal P-glycoprotein, increasing amlodipine clearance.
What to do
Monitor blood pressure during and after rifampin therapy and increase the amlodipine dose as needed. Lower the dose again when rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Rifampin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a potent enzyme inducer and can substantially lower amlodipine exposure, reducing its antihypertensive effect. Loss of blood pressure control may develop over one to two weeks.
How serious is the interaction between Amlodipine-perindopril and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during and after rifampin therapy and increase the amlodipine dose as needed. Lower the dose again when rifampin is stopped.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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