Drug interactions
Amlodipine-perindopril + Salicylates
Severity: Moderate
Amlodipine-perindopril and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-aspirin salicylates at anti-inflammatory doses may blunt the antihypertensive effect of perindopril and add to renal risk. The effect is less than with other NSAIDs and is mostly of concern with high doses or dehydration.
What this interaction means in plain words
Amlodipine-perindopril and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis reduces renal blood flow and sodium excretion, opposing ACE inhibitor effects.
What to do
Monitor blood pressure, creatinine and potassium if high-dose salicylates are used, and keep the patient hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Salicylates?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-aspirin salicylates at anti-inflammatory doses may blunt the antihypertensive effect of perindopril and add to renal risk. The effect is less than with other NSAIDs and is mostly of concern with high doses or dehydration.
How serious is the interaction between Amlodipine-perindopril and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium if high-dose salicylates are used, and keep the patient hydrated.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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