Drug interactions
Amlodipine-perindopril + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Amlodipine-perindopril and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations can cause fluid loss and electrolyte shifts, which may amplify hypotension and impair renal function in patients taking an ACE inhibitor. Raised magnesium may also potentiate calcium channel blocker effects such as hypotension or weakness.
What this interaction means in plain words
Amlodipine-perindopril and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bowel-prep volume depletion and electrolyte changes add to ACE inhibitor and calcium channel blocker hemodynamic effects; magnesium has calcium antagonist activity.
What to do
Ensure adequate hydration during bowel preparation and consider holding perindopril on the day of preparation in patients at risk of dehydration. Check renal function and electrolytes if symptoms or risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osmotic bowel preparations can cause fluid loss and electrolyte shifts, which may amplify hypotension and impair renal function in patients taking an ACE inhibitor. Raised magnesium may also potentiate calcium channel blocker effects such as hypotension or weakness.
How serious is the interaction between Amlodipine-perindopril and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration during bowel preparation and consider holding perindopril on the day of preparation in patients at risk of dehydration. Check renal function and electrolytes if symptoms or risk factors exist.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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