Drug interactions
Amlodipine-perindopril + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Amlodipine-perindopril and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel preparations cause fluid and electrolyte loss, raising the risk of hypotension and acute kidney injury in patients taking an ACE inhibitor. Magnesium shifts may also add to calcium channel blocker effects.
What this interaction means in plain words
Amlodipine-perindopril and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion and electrolyte disturbances combine with ACE inhibitor renal hemodynamic effects and additive vasodilation.
What to do
Maintain good hydration and consider holding perindopril on the day of bowel preparation in high-risk patients. Monitor renal function and electrolytes in patients with kidney disease or volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-perindopril and Sodium sulfate / potassium sulfate / magnesium sulfate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel preparations cause fluid and electrolyte loss, raising the risk of hypotension and acute kidney injury in patients taking an ACE inhibitor. Magnesium shifts may also add to calcium channel blocker effects.
How serious is the interaction between Amlodipine-perindopril and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain good hydration and consider holding perindopril on the day of bowel preparation in high-risk patients. Monitor renal function and electrolytes in patients with kidney disease or volume depletion.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
