Drug interactions
Amlodipine-perindopril + Synthetic human angiotensin ii
Severity: Moderate
Amlodipine-perindopril and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin II is a vasopressor used in vasodilatory shock, and ACE inhibitors may increase the pressor response to it because less endogenous angiotensin II is present. Amlodipine would tend to oppose the pressor effect, making the net response variable.
What this interaction means in plain words
Amlodipine-perindopril and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition reduces endogenous angiotensin II, enhancing sensitivity to exogenous angiotensin II, while calcium channel blockade counteracts vasoconstriction.
What to do
Titrate angiotensin II infusion carefully with continuous blood pressure monitoring in patients on an ACE inhibitor, starting at a low dose. Hold oral antihypertensives during shock.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin II is a vasopressor used in vasodilatory shock, and ACE inhibitors may increase the pressor response to it because less endogenous angiotensin II is present. Amlodipine would tend to oppose the pressor effect, making the net response variable.
How serious is the interaction between Amlodipine-perindopril and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II infusion carefully with continuous blood pressure monitoring in patients on an ACE inhibitor, starting at a low dose. Hold oral antihypertensives during shock.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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