Drug interactions
Amlodipine-perindopril + Trifluoperazine
Severity: Moderate
Amlodipine-perindopril and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine has alpha-blocking properties that can cause orthostatic hypotension, which may add to the effects of perindopril and amlodipine. The effect is usually modest at typical doses.
What this interaction means in plain words
Amlodipine-perindopril and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from phenothiazine alpha-1 blockade with ACE inhibition and calcium channel blockade.
What to do
Monitor blood pressure and orthostatic symptoms, and adjust doses if dizziness or falls occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Trifluoperazine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine has alpha-blocking properties that can cause orthostatic hypotension, which may add to the effects of perindopril and amlodipine. The effect is usually modest at typical doses.
How serious is the interaction between Amlodipine-perindopril and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and adjust doses if dizziness or falls occur.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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