Drug interactions
Amlodipine-perindopril + Trimagnesium
Severity: Minor
Amlodipine-perindopril and Trimagnesium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium has mild calcium-antagonist and vasodilating properties, so taking it with a dihydropyridine calcium channel blocker may add to the blood pressure lowering effect. Dizziness, hypotension or muscle weakness could occur, mainly with parenteral or high-dose magnesium.
What this interaction means in plain words
Amlodipine-perindopril and Trimagnesium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic effect on calcium-dependent vascular smooth muscle tone and neuromuscular transmission.
What to do
Oral magnesium supplements at usual doses rarely need action; monitor blood pressure when magnesium is given intravenously or at high doses with amlodipine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Trimagnesium?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Trimagnesium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Magnesium has mild calcium-antagonist and vasodilating properties, so taking it with a dihydropyridine calcium channel blocker may add to the blood pressure lowering effect. Dizziness, hypotension or muscle weakness could occur, mainly with parenteral or high-dose magnesium.
How serious is the interaction between Amlodipine-perindopril and Trimagnesium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Oral magnesium supplements at usual doses rarely need action; monitor blood pressure when magnesium is given intravenously or at high doses with amlodipine.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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