Drug interactions
Amlodipine-perindopril + Zotepine
Severity: Moderate
Amlodipine-perindopril and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine has alpha-adrenergic blocking activity and can cause orthostatic hypotension. With antihypertensives such as perindopril and amlodipine, blood pressure may fall excessively, especially when zotepine is started or the dose is increased.
What this interaction means in plain words
Amlodipine-perindopril and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from alpha-1 adrenergic blockade (zotepine) and vasodilation or RAAS inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating zotepine, and reduce the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Zotepine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine has alpha-adrenergic blocking activity and can cause orthostatic hypotension. With antihypertensives such as perindopril and amlodipine, blood pressure may fall excessively, especially when zotepine is started or the dose is increased.
How serious is the interaction between Amlodipine-perindopril and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating zotepine, and reduce the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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