Drug interactions
Amlodipine-valsartan + Bumetanide
Severity: Moderate
Amlodipine-valsartan and Bumetanide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding a loop diuretic to an angiotensin receptor blocker can cause marked blood pressure drops and acute renal function decline, especially in volume-depleted patients. Potassium effects oppose each other and are unpredictable.
What this interaction means in plain words
Amlodipine-valsartan and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Bumetanide belongs to Cardiovascular.
Why it happens
Additive hypotensive and volume-depleting effects, with loss of potassium from bumetanide offset by potassium retention from valsartan.
What to do
Monitor blood pressure, serum creatinine, and potassium after starting or changing doses. Consider lowering the diuretic dose if the patient becomes volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Amlodipine-valsartan with Bumetanide?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding a loop diuretic to an angiotensin receptor blocker can cause marked blood pressure drops and acute renal function decline, especially in volume-depleted patients. Potassium effects oppose each other and are unpredictable.
How serious is the interaction between Amlodipine-valsartan and Bumetanide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine, and potassium after starting or changing doses. Consider lowering the diuretic dose if the patient becomes volume depleted.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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