Drug interactions
Amlodipine-valsartan + Digoxin
Severity: Moderate
Amlodipine-valsartan and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan has little consistent effect on digoxin levels, but ARB-related changes in renal function or potassium can alter digoxin exposure and toxicity risk. Amlodipine has minimal effect on digoxin.
What this interaction means in plain words
Amlodipine-valsartan and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Changes in renal function and electrolytes with ARB therapy may alter digoxin clearance and sensitivity.
What to do
Monitor digoxin concentration, renal function and potassium when starting or changing valsartan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Amlodipine-valsartan with Digoxin?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan has little consistent effect on digoxin levels, but ARB-related changes in renal function or potassium can alter digoxin exposure and toxicity risk. Amlodipine has minimal effect on digoxin.
How serious is the interaction between Amlodipine-valsartan and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentration, renal function and potassium when starting or changing valsartan.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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