Drug interactions
Amlodipine-valsartan + Hydrochlorothiazide
Severity: Minor
Amlodipine-valsartan and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide lowers potassium while valsartan raises it, so the combination often offsets potassium changes and is commonly used therapeutically. Additive blood pressure lowering and volume depletion can cause hypotension or renal impairment.
What this interaction means in plain words
Amlodipine-valsartan and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Complementary effects on renal potassium handling and additive antihypertensive action via diuresis and RAAS blockade.
What to do
Monitor blood pressure, electrolytes and renal function after initiation or dose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Amlodipine-valsartan with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide lowers potassium while valsartan raises it, so the combination often offsets potassium changes and is commonly used therapeutically. Additive blood pressure lowering and volume depletion can cause hypotension or renal impairment.
How serious is the interaction between Amlodipine-valsartan and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, electrolytes and renal function after initiation or dose changes.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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