Drug interactions
Amlodipine-valsartan + Pravastatin
Severity: Minor
Amlodipine-valsartan and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are OATP1B1 substrates, so competition for hepatic uptake is theoretically possible. No clinically important change in valsartan or pravastatin effect or increase in myopathy is established.
What this interaction means in plain words
Amlodipine-valsartan and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Pravastatin belongs to Cardiovascular.
Why it happens
Theoretical competition at OATP1B1-mediated hepatic uptake.
What to do
No dose adjustment is needed. Counsel the patient to report unexplained muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Pravastatin
Frequently asked questions
Can I take Amlodipine-valsartan with Pravastatin?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are OATP1B1 substrates, so competition for hepatic uptake is theoretically possible. No clinically important change in valsartan or pravastatin effect or increase in myopathy is established.
How serious is the interaction between Amlodipine-valsartan and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Counsel the patient to report unexplained muscle symptoms.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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