Drug interactions
Amlodipine-valsartan + Sotalol
Severity: Moderate
Amlodipine-valsartan and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol and the amlodipine-valsartan combination lower blood pressure additively and may cause bradycardia and hypotension. Valsartan can raise potassium whereas hyperkalemia or hypokalemia from other causes affects sotalol-related arrhythmia risk, and valsartan is harmful in pregnancy.
What this interaction means in plain words
Amlodipine-valsartan and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect from beta-blockade, vasodilation and renin-angiotensin blockade.
What to do
Monitor blood pressure, heart rate, ECG (QT) and serum potassium and magnesium. Adjust doses if hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Amlodipine-valsartan with Sotalol?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotalol and the amlodipine-valsartan combination lower blood pressure additively and may cause bradycardia and hypotension. Valsartan can raise potassium whereas hyperkalemia or hypokalemia from other causes affects sotalol-related arrhythmia risk, and valsartan is harmful in pregnancy.
How serious is the interaction between Amlodipine-valsartan and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, ECG (QT) and serum potassium and magnesium. Adjust doses if hypotension or bradycardia develops.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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