Drug interactions
Amlodipine-valsartan + Temsirolimus
Severity: Moderate
Amlodipine-valsartan and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
mTOR inhibitors can cause angioedema, and the risk appears higher when combined with agents that also affect it, including calcium channel blockers and angiotensin receptor blockers. Valsartan itself is also associated with angioedema, so cumulative risk is possible.
What this interaction means in plain words
Amlodipine-valsartan and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Additive angioedema risk; the exact mechanism is not fully established.
What to do
Counsel the patient to seek urgent care for swelling of the face, lips, tongue or throat. Stop the offending drugs if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Amlodipine-valsartan with Temsirolimus?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. mTOR inhibitors can cause angioedema, and the risk appears higher when combined with agents that also affect it, including calcium channel blockers and angiotensin receptor blockers. Valsartan itself is also associated with angioedema, so cumulative risk is possible.
How serious is the interaction between Amlodipine-valsartan and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to seek urgent care for swelling of the face, lips, tongue or throat. Stop the offending drugs if angioedema occurs.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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