Drug interactions
Ammonium chloride + Lisdexamfetamine
Severity: Moderate
Ammonium chloride and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ammonium chloride acidifies the urine, which increases renal elimination of amphetamine. This can reduce the exposure and duration of lisdexamfetamine's active metabolite, so benefit may be diminished.
What this interaction means in plain words
Ammonium chloride and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Urinary acidification increases ionization of dextroamphetamine, reducing tubular reabsorption and increasing renal clearance.
What to do
Monitor clinical response and consider a dose adjustment if urinary acidifiers are used regularly. Avoid unnecessary acidifying agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Ammonium chloride with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Ammonium chloride and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ammonium chloride acidifies the urine, which increases renal elimination of amphetamine. This can reduce the exposure and duration of lisdexamfetamine's active metabolite, so benefit may be diminished.
How serious is the interaction between Ammonium chloride and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider a dose adjustment if urinary acidifiers are used regularly. Avoid unnecessary acidifying agents.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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