Drug interactions
Lisdexamfetamine + Rasagiline
Severity: Contraindicated
Lisdexamfetamine and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines release monoamines, and MAO inhibition by rasagiline reduces their breakdown, risking hypertensive crisis and serotonin syndrome. Labeling prohibits use during and for 14 days after an MAOI.
What this interaction means in plain words
Lisdexamfetamine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lisdexamfetamine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition potentiates amphetamine-induced monoamine release.
What to do
Do not co-administer; keep a 14-day interval after rasagiline. Use a non-stimulant therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
- Lisdexamfetamine + Selegiline Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Rasagiline?
MediHelp rates the interaction as contraindicated. Lisdexamfetamine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amphetamines release monoamines, and MAO inhibition by rasagiline reduces their breakdown, risking hypertensive crisis and serotonin syndrome. Labeling prohibits use during and for 14 days after an MAOI.
How serious is the interaction between Lisdexamfetamine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; keep a 14-day interval after rasagiline. Use a non-stimulant therapy.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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