Drug interactions
Lisdexamfetamine + Procarbazine
Severity: Contraindicated
Lisdexamfetamine and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO-inhibiting properties, and amphetamines release catecholamines that are then not degraded. This can precipitate hypertensive crisis. The combination should not be used.
What this interaction means in plain words
Lisdexamfetamine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lisdexamfetamine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition by procarbazine potentiates amphetamine-induced catecholamine release.
What to do
Avoid the combination, including 14 days after procarbazine. Use non-stimulant alternatives.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
- Lisdexamfetamine + Selegiline Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Procarbazine?
MediHelp rates the interaction as contraindicated. Lisdexamfetamine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting properties, and amphetamines release catecholamines that are then not degraded. This can precipitate hypertensive crisis. The combination should not be used.
How serious is the interaction between Lisdexamfetamine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, including 14 days after procarbazine. Use non-stimulant alternatives.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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