Drug interactions
Lisdexamfetamine + Phenelzine
Severity: Contraindicated
Lisdexamfetamine and Phenelzine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines release large amounts of norepinephrine, dopamine and serotonin, and MAO inhibition prevents their breakdown. This can cause hypertensive crisis, hyperthermia and serotonin syndrome. Labeling contraindicates use during and for 14 days after an MAOI.
What this interaction means in plain words
Lisdexamfetamine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lisdexamfetamine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Irreversible MAO inhibition lets released monoamines accumulate, producing excessive adrenergic and serotonergic stimulation.
What to do
Do not co-administer, and separate by at least 14 days after stopping phenelzine. Choose a non-stimulant alternative if ADHD or binge-eating treatment is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
- Lisdexamfetamine + Selegiline Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Phenelzine?
MediHelp rates the interaction as contraindicated. Lisdexamfetamine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amphetamines release large amounts of norepinephrine, dopamine and serotonin, and MAO inhibition prevents their breakdown. This can cause hypertensive crisis, hyperthermia and serotonin syndrome. Labeling contraindicates use during and for 14 days after an MAOI.
How serious is the interaction between Lisdexamfetamine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, and separate by at least 14 days after stopping phenelzine. Choose a non-stimulant alternative if ADHD or binge-eating treatment is needed.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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