Drug interactions
Lisdexamfetamine + Safinamide
Severity: Contraindicated
Lisdexamfetamine and Safinamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide inhibits MAO-B and can allow amphetamine-released monoamines to accumulate, with risk of hypertensive crisis and serotonin syndrome. Labeling for amphetamines contraindicates MAOIs.
What this interaction means in plain words
Lisdexamfetamine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lisdexamfetamine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
MAO inhibition potentiates amphetamine-induced monoamine release.
What to do
Avoid concurrent use and keep a 14-day gap after safinamide. Seek alternative treatment for ADHD or binge-eating disorder.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Selegiline Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Safinamide?
MediHelp rates the interaction as contraindicated. Lisdexamfetamine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide inhibits MAO-B and can allow amphetamine-released monoamines to accumulate, with risk of hypertensive crisis and serotonin syndrome. Labeling for amphetamines contraindicates MAOIs.
How serious is the interaction between Lisdexamfetamine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep a 14-day gap after safinamide. Seek alternative treatment for ADHD or binge-eating disorder.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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