Drug interactions
Amobarbital + Apremilast
Severity: Moderate
Amobarbital and Apremilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is an enzyme inducer and may lower apremilast concentrations. This can reduce its therapeutic benefit in psoriasis or psoriatic arthritis.
What this interaction means in plain words
Amobarbital and Apremilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Apremilast belongs to Miscellaneous.
Why it happens
Induction of CYP3A4-mediated apremilast metabolism by the barbiturate.
What to do
Apremilast labeling advises avoiding strong CYP3A4 inducers; choose a non-inducing alternative to the barbiturate. If coadministered, monitor for loss of efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Apremilast
- Apalutamide + Apremilast Major
- Apremilast + Carbamazepine Major
- Apremilast + Efavirenz Major
- Apremilast + Enzalutamide Major
- Apremilast + Phenytoin Major
- Apremilast + Rifampicin Major
Frequently asked questions
Can I take Amobarbital with Apremilast?
MediHelp rates the interaction as moderate. Amobarbital and Apremilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital is an enzyme inducer and may lower apremilast concentrations. This can reduce its therapeutic benefit in psoriasis or psoriatic arthritis.
How serious is the interaction between Amobarbital and Apremilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Apremilast labeling advises avoiding strong CYP3A4 inducers; choose a non-inducing alternative to the barbiturate. If coadministered, monitor for loss of efficacy.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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