Drug interactions
Amobarbital + Argatroban
Severity: Minor
Amobarbital and Argatroban: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are enzyme inducers and could theoretically lower argatroban exposure. Argatroban is cleared mainly by hepatic metabolism, but CYP3A4/5 contributes only a minor share, and it is given by titrated infusion monitored with aPTT. Clinically meaningful loss of anticoagulation is unlikely.
What this interaction means in plain words
Amobarbital and Argatroban have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Argatroban belongs to Cardiovascular.
Why it happens
Possible induction of hepatic CYP3A4/5 by amobarbital, which is a minor elimination pathway for argatroban.
What to do
No empirical dose change is needed; titrate argatroban to aPTT as usual and reassess if anticoagulation response is unexpectedly low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Amobarbital with Argatroban?
MediHelp rates the interaction as minor. Amobarbital and Argatroban have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates are enzyme inducers and could theoretically lower argatroban exposure. Argatroban is cleared mainly by hepatic metabolism, but CYP3A4/5 contributes only a minor share, and it is given by titrated infusion monitored with aPTT. Clinically meaningful loss of anticoagulation is unlikely.
How serious is the interaction between Amobarbital and Argatroban?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; titrate argatroban to aPTT as usual and reassess if anticoagulation response is unexpectedly low.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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