Drug interactions
Amobarbital + Aripiprazole
Severity: Moderate
Amobarbital and Aripiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, so the combination may lead to increased sedation and impaired alertness. Amobarbital may also lower aripiprazole levels by inducing CYP3A4.
What this interaction means in plain words
Amobarbital and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Aripiprazole belongs to Central Nervous System.
Why it happens
Additive CNS depression and barbiturate induction of CYP3A4 metabolism of aripiprazole.
What to do
Monitor sedation and psychiatric response. Aripiprazole labeling suggests doubling the dose with strong CYP3A4 inducers, so adjust the dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Amobarbital with Aripiprazole?
MediHelp rates the interaction as moderate. Amobarbital and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, so the combination may lead to increased sedation and impaired alertness. Amobarbital may also lower aripiprazole levels by inducing CYP3A4.
How serious is the interaction between Amobarbital and Aripiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and psychiatric response. Aripiprazole labeling suggests doubling the dose with strong CYP3A4 inducers, so adjust the dose to response.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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