Drug interactions
Amobarbital + Atazanavir
Severity: Major
Amobarbital and Atazanavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may reduce atazanavir plasma concentrations, which can compromise virologic suppression and encourage resistance. Boosted regimens are particularly sensitive to inducers of CYP3A4.
What this interaction means in plain words
Amobarbital and Atazanavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Atazanavir belongs to Anti Virals.
Why it happens
Barbiturate induction of CYP3A4 (and possibly UGT) increases atazanavir clearance.
What to do
Avoid concomitant use and select a non-inducing sedative or anticonvulsant. If it cannot be avoided, monitor HIV viral load and consider atazanavir trough levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Amobarbital with Atazanavir?
MediHelp rates the interaction as major. Amobarbital and Atazanavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital may reduce atazanavir plasma concentrations, which can compromise virologic suppression and encourage resistance. Boosted regimens are particularly sensitive to inducers of CYP3A4.
How serious is the interaction between Amobarbital and Atazanavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select a non-inducing sedative or anticonvulsant. If it cannot be avoided, monitor HIV viral load and consider atazanavir trough levels.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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