Drug interactions
Amobarbital + Benazepril
Severity: Moderate
Amobarbital and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can lower blood pressure and may enhance the hypotensive action of ACE inhibitors, with a risk of dizziness or orthostasis.
What this interaction means in plain words
Amobarbital and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Benazepril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from CNS depression and vasodilation by the barbiturate together with ACE inhibition.
What to do
Monitor blood pressure, especially on starting the barbiturate, and counsel patients to rise slowly. Reduce the benazepril dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Benazepril?
MediHelp rates the interaction as moderate. Amobarbital and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates can lower blood pressure and may enhance the hypotensive action of ACE inhibitors, with a risk of dizziness or orthostasis.
How serious is the interaction between Amobarbital and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially on starting the barbiturate, and counsel patients to rise slowly. Reduce the benazepril dose if hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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