Drug interactions
Amobarbital + Buspirone
Severity: Moderate
Amobarbital and Buspirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital can induce CYP3A4, the main enzyme that metabolises buspirone, and so may reduce its plasma levels and anxiolytic effect. Additive drowsiness is also possible.
What this interaction means in plain words
Amobarbital and Buspirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Buspirone belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 increases buspirone clearance.
What to do
Monitor anxiolytic response and increase the buspirone dose if needed. Reassess the dose if amobarbital is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amobarbital and Buspirone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Amobarbital with Buspirone?
MediHelp rates the interaction as moderate. Amobarbital and Buspirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital can induce CYP3A4, the main enzyme that metabolises buspirone, and so may reduce its plasma levels and anxiolytic effect. Additive drowsiness is also possible.
How serious is the interaction between Amobarbital and Buspirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor anxiolytic response and increase the buspirone dose if needed. Reassess the dose if amobarbital is discontinued.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
