Drug interactions
Amobarbital + Celecoxib
Severity: Minor
Amobarbital and Celecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may lower celecoxib concentrations, potentially reducing analgesic or anti-inflammatory effect. The effect is probably modest and rarely clinically important.
What this interaction means in plain words
Amobarbital and Celecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Celecoxib belongs to Musculoskeletal.
Why it happens
Amobarbital induces CYP2C9 and other hepatic enzymes, increasing celecoxib clearance.
What to do
Monitor for loss of pain or inflammation control and increase celecoxib within labeled limits if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Celecoxib?
MediHelp rates the interaction as minor. Amobarbital and Celecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes and may lower celecoxib concentrations, potentially reducing analgesic or anti-inflammatory effect. The effect is probably modest and rarely clinically important.
How serious is the interaction between Amobarbital and Celecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of pain or inflammation control and increase celecoxib within labeled limits if needed.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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