Drug interactions
Amobarbital + Chloramphenicol
Severity: Moderate
Amobarbital and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits hepatic metabolism of barbiturates and can increase their sedative effect. Conversely, barbiturates induce liver enzymes and may lower chloramphenicol concentrations, which risks therapeutic failure of the antibiotic.
What this interaction means in plain words
Amobarbital and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Chloramphenicol inhibits CYP-mediated barbiturate metabolism, while amobarbital induces enzymes that metabolize chloramphenicol.
What to do
Monitor sedation and respiratory status, and consider reducing the amobarbital dose. Monitor chloramphenicol serum concentrations and clinical response where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Chloramphenicol?
MediHelp rates the interaction as moderate. Amobarbital and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol inhibits hepatic metabolism of barbiturates and can increase their sedative effect. Conversely, barbiturates induce liver enzymes and may lower chloramphenicol concentrations, which risks therapeutic failure of the antibiotic.
How serious is the interaction between Amobarbital and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and consider reducing the amobarbital dose. Monitor chloramphenicol serum concentrations and clinical response where available.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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