Drug interactions
Amobarbital + Chlorpheniramine
Severity: Moderate
Amobarbital and Chlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause drowsiness, so together they can produce marked sedation and impaired alertness. Amobarbital may also lower chlorpheniramine levels through enzyme induction.
What this interaction means in plain words
Amobarbital and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Chlorpheniramine belongs to Respiratory.
Why it happens
Additive CNS depression, plus barbiturate induction of CYP3A4-mediated metabolism.
What to do
Advise against driving and alcohol use, and consider a non-sedating antihistamine. Reduce doses if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Amobarbital with Chlorpheniramine?
MediHelp rates the interaction as moderate. Amobarbital and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause drowsiness, so together they can produce marked sedation and impaired alertness. Amobarbital may also lower chlorpheniramine levels through enzyme induction.
How serious is the interaction between Amobarbital and Chlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against driving and alcohol use, and consider a non-sedating antihistamine. Reduce doses if oversedation occurs.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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