Drug interactions
Amobarbital + Cilostazol
Severity: Moderate
Amobarbital and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are inducers of CYP3A4 and can lower plasma concentrations of cilostazol and its active metabolites. This may reduce the effect on intermittent claudication symptoms.
What this interaction means in plain words
Amobarbital and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Cilostazol belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 by amobarbital increases cilostazol metabolism.
What to do
Monitor claudication symptoms and consider an alternative sedative or hypnotic; adjust cilostazol only if clinical response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Cilostazol?
MediHelp rates the interaction as moderate. Amobarbital and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are inducers of CYP3A4 and can lower plasma concentrations of cilostazol and its active metabolites. This may reduce the effect on intermittent claudication symptoms.
How serious is the interaction between Amobarbital and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor claudication symptoms and consider an alternative sedative or hypnotic; adjust cilostazol only if clinical response is lost.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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