Drug interactions
Amobarbital + Desipramine
Severity: Moderate
Amobarbital and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combining them may increase drowsiness and impair psychomotor function. Barbiturate enzyme induction may also lower desipramine levels, and tricyclics can lower the seizure threshold.
What this interaction means in plain words
Amobarbital and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Desipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression, with barbiturate induction of hepatic metabolism of desipramine.
What to do
Monitor sedation and antidepressant response, and adjust the desipramine dose, using plasma levels if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Amobarbital with Desipramine?
MediHelp rates the interaction as moderate. Amobarbital and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combining them may increase drowsiness and impair psychomotor function. Barbiturate enzyme induction may also lower desipramine levels, and tricyclics can lower the seizure threshold.
How serious is the interaction between Amobarbital and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and antidepressant response, and adjust the desipramine dose, using plasma levels if available.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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