Drug interactions
Amobarbital + Doxepin
Severity: Moderate
Amobarbital and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant, and with a barbiturate it produces additive drowsiness and psychomotor impairment. The barbiturate may also induce metabolism of doxepin, reducing its antidepressant effect.
What this interaction means in plain words
Amobarbital and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Doxepin belongs to Dermatology.
Why it happens
Additive CNS depression, plus hepatic enzyme induction by the barbiturate increasing tricyclic clearance.
What to do
Monitor for oversedation and for loss of antidepressant response, adjusting the doxepin dose if needed. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Amobarbital with Doxepin?
MediHelp rates the interaction as moderate. Amobarbital and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant, and with a barbiturate it produces additive drowsiness and psychomotor impairment. The barbiturate may also induce metabolism of doxepin, reducing its antidepressant effect.
How serious is the interaction between Amobarbital and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and for loss of antidepressant response, adjusting the doxepin dose if needed. Advise against driving until the response is known.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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