Drug interactions
Amobarbital + Dutasteride-tamsulosin
Severity: Minor
Amobarbital and Dutasteride-tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces hepatic enzymes including CYP3A4, which may lower tamsulosin and dutasteride concentrations. This could reduce their effectiveness for urinary symptoms and prostate size.
What this interaction means in plain words
Amobarbital and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Barbiturate induction of CYP3A4 increases metabolic clearance of tamsulosin and dutasteride.
What to do
Monitor urinary symptom control if amobarbital is used long term. Adjust therapy if the response to tamsulosin or dutasteride declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Dutasteride-tamsulosin?
MediHelp rates the interaction as minor. Amobarbital and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amobarbital induces hepatic enzymes including CYP3A4, which may lower tamsulosin and dutasteride concentrations. This could reduce their effectiveness for urinary symptoms and prostate size.
How serious is the interaction between Amobarbital and Dutasteride-tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom control if amobarbital is used long term. Adjust therapy if the response to tamsulosin or dutasteride declines.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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