Drug interactions
Amobarbital + Felodipine
Severity: Moderate
Amobarbital and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and can substantially reduce felodipine concentrations, causing loss of antihypertensive effect. Felodipine is highly dependent on CYP3A4 first-pass metabolism, so it is particularly susceptible.
What this interaction means in plain words
Amobarbital and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Felodipine belongs to Cardiovascular.
Why it happens
Amobarbital induces CYP3A4, accelerating felodipine metabolism.
What to do
Monitor blood pressure and increase the felodipine dose if needed, or choose an alternative antihypertensive. Reassess the dose when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Felodipine?
MediHelp rates the interaction as moderate. Amobarbital and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and can substantially reduce felodipine concentrations, causing loss of antihypertensive effect. Felodipine is highly dependent on CYP3A4 first-pass metabolism, so it is particularly susceptible.
How serious is the interaction between Amobarbital and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and increase the felodipine dose if needed, or choose an alternative antihypertensive. Reassess the dose when the barbiturate is stopped.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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