Drug interactions
Amobarbital + Hydrochlorothiazide-losartan
Severity: Minor
Amobarbital and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates may induce metabolism of losartan and reduce its activation, possibly weakening blood pressure control. Barbiturates can also add to orthostatic hypotension caused by the antihypertensives.
What this interaction means in plain words
Amobarbital and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Barbiturate induction of CYP2C9 and CYP3A4 may lower losartan and active metabolite exposure; additive hypotensive effect.
What to do
Monitor blood pressure when amobarbital is started or stopped and adjust antihypertensive dosing if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Amobarbital and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates may induce metabolism of losartan and reduce its activation, possibly weakening blood pressure control. Barbiturates can also add to orthostatic hypotension caused by the antihypertensives.
How serious is the interaction between Amobarbital and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when amobarbital is started or stopped and adjust antihypertensive dosing if needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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