Drug interactions
Amobarbital + Levothyroxine
Severity: Moderate
Amobarbital and Levothyroxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can speed up levothyroxine metabolism, which may raise dose requirements and lead to hypothyroidism in treated patients.
What this interaction means in plain words
Amobarbital and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Levothyroxine belongs to Endocrine.
Why it happens
Hepatic enzyme induction increases levothyroxine clearance.
What to do
Check TSH after starting or stopping amobarbital, and adjust the levothyroxine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Levothyroxine
Frequently asked questions
Can I take Amobarbital with Levothyroxine?
MediHelp rates the interaction as moderate. Amobarbital and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates can speed up levothyroxine metabolism, which may raise dose requirements and lead to hypothyroidism in treated patients.
How serious is the interaction between Amobarbital and Levothyroxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH after starting or stopping amobarbital, and adjust the levothyroxine dose accordingly.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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