Drug interactions
Amobarbital + Loxapine
Severity: Moderate
Amobarbital and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause excessive sedation, impaired psychomotor performance and, at higher doses, respiratory depression. Loxapine can also lower the seizure threshold, which complicates barbiturate withdrawal.
What this interaction means in plain words
Amobarbital and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A enhancement by the barbiturate and dopamine, histamine and muscarinic blockade by loxapine.
What to do
Start with lower doses and monitor sedation and respiratory status, especially in elderly or debilitated patients. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Amobarbital with Loxapine?
MediHelp rates the interaction as moderate. Amobarbital and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause excessive sedation, impaired psychomotor performance and, at higher doses, respiratory depression. Loxapine can also lower the seizure threshold, which complicates barbiturate withdrawal.
How serious is the interaction between Amobarbital and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower doses and monitor sedation and respiratory status, especially in elderly or debilitated patients. Advise patients to avoid driving and alcohol.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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