Drug interactions
Amobarbital + Maprotiline
Severity: Moderate
Amobarbital and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use increases sedation and CNS depression. Maprotiline lowers the seizure threshold and barbiturates may speed its clearance, so antidepressant effect may be reduced while seizure risk persists, particularly during barbiturate withdrawal.
What this interaction means in plain words
Amobarbital and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus barbiturate induction of hepatic enzymes that may lower maprotiline concentrations.
What to do
Monitor sedation and antidepressant response, and consider a maprotiline dose adjustment if response is lost. Avoid abrupt barbiturate discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Amobarbital with Maprotiline?
MediHelp rates the interaction as moderate. Amobarbital and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use increases sedation and CNS depression. Maprotiline lowers the seizure threshold and barbiturates may speed its clearance, so antidepressant effect may be reduced while seizure risk persists, particularly during barbiturate withdrawal.
How serious is the interaction between Amobarbital and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and antidepressant response, and consider a maprotiline dose adjustment if response is lost. Avoid abrupt barbiturate discontinuation.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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